The Australian Centre for Quantitative Imaging (ACQI) will bring the power of quantitative imaging to researchers and bridge the translational gap to clinical implementation of associated analytics methods. The centre will provide a creative hub for designing and experimenting with analytics methods, applying those methods to research questions, and mediating access to patient imaging data for innovation and commercialisation. This highly collaborative centre will bring together expertise spanning medical and technical disciplines. Through national and international linkage, Western Australia will be placed at the leading edge of this rapidly developing field. ACQI will facilitate training and workforce development in a rapidly expanding area of medicine. ACQI will be the conduit to provide Western Australian patients with access to novel technologies and techniques, which can benefit health outcomes with demonstrated cost-effectiveness.